Molecular Mapping of the RNA Cap 2′-O-Methyltransferase Activation Interface between Severe Acute Respiratory Syndrome Coronavirus nsp10 and nsp16

Several protein-protein interactions within the SARS-CoV proteome have been identified, one of them being between non-structural proteins nsp10 and nsp16. In this work, we have mapped key residues on the nsp10 surface involved in this interaction. Alanine-scanning mutagenesis, bioinformatics, and mo...

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Detalhes bibliográficos
Main Authors: Lugari, Adrien, Betzi, Stephane, Decroly, Etienne, Bonnaud, Emmanuel, Hermant, Aurélie, Guillemot, Jean-Claude, Debarnot, Claire, Borg, Jean-Paul, Bouvet, Mickaël, Canard, Bruno, Morelli, Xavier, Lécine, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963367/
https://ncbi.nlm.nih.gov/pubmed/20699222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120014
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