Ligands for FKBP12 Increase Ca(2+) Influx and Protein Synthesis to Improve Skeletal Muscle Function

Rapamycin at high doses (2–10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes are found with SLF (synthetic li...

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Dettagli Bibliografici
Autori principali: Lee, Chang Seok, Georgiou, Dimitra K., Dagnino-Acosta, Adan, Xu, Jianjun, Ismailov, Iskander I., Knoblauch, Mark, Monroe, Tanner O., Ji, RuiRui, Hanna, Amy D., Joshi, Aditya D., Long, Cheng, Oakes, Joshua, Tran, Ted, Corona, Benjamin T., Lorca, Sabina, Ingalls, Christopher P., Narkar, Vihang A., Lanner, Johanna T., Bayle, J. Henri, Durham, William J., Hamilton, Susan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162161/
https://ncbi.nlm.nih.gov/pubmed/25053409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586289
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