Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation

Rare missense mutations in the von Willebrand factor (VWF) A3 domain that disrupt collagen binding have been found in patients with a mild bleeding phenotype. However, the analysis of these aberrant VWF-collagen interactions has been limited. Here, we have developed mouse models of collagen-binding...

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Autores principales: Shida, Yasuaki, Rydz, Natalia, Stegner, David, Brown, Christine, Mewburn, Jeffrey, Sponagle, Kate, Danisment, Ozge, Crawford, Bredon, Vidal, Barbara, Hegadorn, Carol A., Pruss, Cynthia M., Nieswandt, Bernhard, Lillicrap, David
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2014
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162109/
https://ncbi.nlm.nih.gov/pubmed/25051961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-09-521484
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