The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans

The effects of sex, ethnicity, and genetic polymorphism on hepatic CYP2B6 (cytochrome P450 2B6) expression and activity were previously demonstrated in vitro. Race/ethnic differences in CYP2B6 genotype and phenotype were observed only in women. To identify important covariates associated with interi...

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Hlavní autoři: Ilic, Katarina, Hawke, Roy L., Thirumaran, Ranjit K., Schuetz, Erin G., Hull, J. Heyward, Kashuba, Angela D.M., Stewart, Paul W., Lindley, Celeste M., Chen, Mei-Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162003/
https://ncbi.nlm.nih.gov/pubmed/23238783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048108
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