CYP2B6 and bupropion’s smoking cessation pharmacology: the role of hydroxybupropion

Bupropion is indicated to promote smoking cessation. Animal studies suggest that bupropion’s major metabolite hydroxybupropion can mediate bupropion’s pharmacologic activity. We measured plasma bupropion and metabolite levels in a double-blind, placebo controlled, randomized smoking cessation trial....

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Main Authors: Zhu, Andy Z.X., Cox, Lisa Sanderson, Nollen, Nikki, Faseru, Babalola, Okuyemi, Kolawole S., Ahluwalia, Jasjit S, Benowitz, Neal L, Tyndale, Rachel F.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729209/
https://ncbi.nlm.nih.gov/pubmed/23149928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2012.186
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