dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages

BACKGROUND: SAMHD1 degrades deoxyribonucleotides (dNTPs), suppressing viral DNA synthesis in macrophages. Recently, viral protein X (Vpx) of HIV-2/SIVsm was shown to target SAMHD1 for proteosomal degradation and led to elevation of dNTP levels, which in turn accelerated proviral DNA synthesis of len...

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Bibliografiske detaljer
Main Authors: Hollenbaugh, Joseph A, Tao, Sijia, Lenzi, Gina M, Ryu, Sulryung, Kim, Dong-Hyun, Diaz-Griffero, Felipe, Schinazi, Raymond F, Kim, Baek
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161909/
https://ncbi.nlm.nih.gov/pubmed/25158827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0063-2
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