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Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics()
The bicyclic β-lactam/2-pyrrolidine precursor to all carbapenem antibiotics is biosynthesized by attachment of a carboxymethylene unit to C5 of L-proline followed by β-lactam ring closure. Carbapenem synthase (CarC), an Fe(II)- and 2-(oxo)glutarate-dependent (Fe/2OG) oxygenase, then inverts the C5 c...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160820/ https://ncbi.nlm.nih.gov/pubmed/24604200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1248000 |
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