The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers

Polymorphisms and somatic mutations in Flap Endonuclease 1 (FEN1), an essential enzyme involved in DNA replication and repair, can lead to functional deficiencies of the FEN1 protein and a predisposition to cancer. We identified a FEN1 germline mutation which changed residue E359 to K in a patient w...

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Detalhes bibliográficos
Main Authors: Chung, Lin, Onyango, David, Guo, Zhigang, Jia, Pingping, Dai, Huifang, Liu, Songbai, Zhou, Mian, Lin, Weiqiang, Pang, Insun, Li, Hongzhi, Yuan, Yate-Ching, Huang, Qin, Zheng, Li, Lopes, Judith, Nicolas, Alain, Chai, Weihang, Raz, Dan, Reckamp, Karen L., Shen, Binghui
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160428/
https://ncbi.nlm.nih.gov/pubmed/24608430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.19
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