Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

DNA replication and repair are critical processes for all living organisms to ensure faithful duplication and transmission of genetic information. Flap endonuclease 1 (Fen1), a structure-specific nuclease, plays an important role in multiple DNA metabolic pathways and maintenance of genome stability...

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Detalhes bibliográficos
Main Authors: Zheng, Li, Dai, Huifang, Hegde, Muralidhar L, Zhou, Mian, Guo, Zhigang, Wu, Xiwei, Wu, Jun, Su, Lei, Zhong, Xueyan, Mitra, Sankar, Huang, Qin, Kernstine, Kemp H, Pfeifer, Gerd P, Shen, Binghui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129403/
https://ncbi.nlm.nih.gov/pubmed/21383776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.35
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