In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation

Classical genetic approaches to examine the requirements of genes for T cell differentiation during infection are time-consuming. Here we developed a pooled approach to screen 30–100+ genes individually in separate antigen-specific T cells during infection using short hairpin RNAs in a microRNA cont...

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Hlavní autoři: Chen, Runqiang, Bélanger, Simon, Frederick, Megan A., Li, Bin, Johnston, Robert J., Xiao, Nengming, Liu, Yun-Cai, Sharma, Sonia, Peters, Bjoern, Rao, Anjana, Crotty, Shane, Pipkin, Matthew E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160313/
https://ncbi.nlm.nih.gov/pubmed/25148027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.08.002
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