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MicroRNA-directed program of cytotoxic CD8(+) T-cell differentiation
Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTLs, and that deletion or depletion of Dicer in mouse or human activated CD8(+) T cells causes up-regulation of perforin, granzym...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3831973/ https://ncbi.nlm.nih.gov/pubmed/24163352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317191110 |
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