MicroRNA-directed program of cytotoxic CD8(+) T-cell differentiation

Acquisition of effector properties is a key step in the generation of cytotoxic T lymphocytes (CTLs). Here we show that inflammatory signals regulate Dicer expression in CTLs, and that deletion or depletion of Dicer in mouse or human activated CD8(+) T cells causes up-regulation of perforin, granzym...

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Bibliografiske detaljer
Main Authors: Trifari, Sara, Pipkin, Matthew E., Bandukwala, Hozefa S., Äijö, Tarmo, Bassein, Jed, Chen, Runqiang, Martinez, Gustavo J., Rao, Anjana
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831973/
https://ncbi.nlm.nih.gov/pubmed/24163352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317191110
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