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Activation of Cre Recombinase Alone Can Induce Complete Tumor Regression
The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediate...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160265/ https://ncbi.nlm.nih.gov/pubmed/25208064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107589 |
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