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Impact of the K24N mutation on the transactivation domain of p53 and its binding to MDM2
The level of the p53 transcription factor is negatively regulated by the E3 ubiguitin ligase murine double minute clone 2 (MDM2). The interaction between p53 and MDM2 is essential for the maintenance of genomic integrity for most eukaryotes. Previous structural studies revealed that MDM2 binds to p5...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160123/ https://ncbi.nlm.nih.gov/pubmed/23609977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24310 |
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