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The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans
The cis and trans conformations of the Xaa–Pro (Xaa: any amino acid) peptide bond are thermodynamically stable while other peptide bonds strongly prefer trans. The effect of proline cis–trans isomerization on protein binding has not been thoroughly investigated. In this study, computer simulations w...
Shranjeno v:
| izdano v: | Arch Biochem Biophys |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5444545/ https://ncbi.nlm.nih.gov/pubmed/25840370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2015.03.021 |
| Oznake: |
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