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Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
PURPOSE. In the pathogenesis of diabetic retinopathy, matrix metalloproteinase (MMP)-9 damages retinal mitochondria, activating the apoptotic machinery. Transcription of MMP-9 is regulated by nuclear factor kappa B (NF-κB), and the activation of NF-κB is modulated by the acetylation of its p65 subun...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Association for Research in Vision and Ophthalmology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160094/ https://ncbi.nlm.nih.gov/pubmed/24894401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14383 |
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