Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy

PURPOSE. In the pathogenesis of diabetic retinopathy, matrix metalloproteinase (MMP)-9 damages retinal mitochondria, activating the apoptotic machinery. Transcription of MMP-9 is regulated by nuclear factor kappa B (NF-κB), and the activation of NF-κB is modulated by the acetylation of its p65 subun...

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Bibliografiske detaljer
Main Authors: Kowluru, Renu A., Santos, Julia M., Zhong, Qing
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2014
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160094/
https://ncbi.nlm.nih.gov/pubmed/24894401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14383
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