Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases

Measles virus (MV) is highly infectious and infects dendritic cells (DCs) for viral dissemination. DCs express RIG-I-like receptors (RLRs) RIG-I and Mda5 that sense MV to induce antiviral type I interferon (IFN) responses. Dephosphorylation of RIG-I and Mda5 by PP1 phosphatases is required for their...

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Huvudupphovsmän: Mesman, Annelies W., Zijlstra-Willems, Esther M., Kaptein, Tanja M., de Swart, Rik L., Davis, Meredith E., Ludlow, Martin, Duprex, W. Paul, Gack, Michaela U., Gringhuis, Sonja I., Geijtenbeek, Teunis B.H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159752/
https://ncbi.nlm.nih.gov/pubmed/25011106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.06.008
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