Antagonism of the Phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5

The cytosolic sensor MDA5 is crucial for antiviral innate immune defense against various RNA viruses including measles virus; as such, many viruses have evolved strategies to antagonize the antiviral activity of MDA5. Here, we show that measles virus escapes MDA5 detection by targeting the phosphata...

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Bibliographic Details
Main Authors: Davis, Meredith E., Wang, May K., Rennick, Linda J., Full, Florian, Gableske, Sebastian, Mesman, Annelies W., Gringhuis, Sonja I., Geijtenbeek, Teunis B.H., Duprex, W. Paul, Gack, Michaela U.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120867/
https://ncbi.nlm.nih.gov/pubmed/25011105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.06.007
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