Exponential increases of RNA virus fitness during large population transmissions.

The great adaptability shown by RNA viruses is a consequence of their high mutation rates. Here we investigate the kinetics of virus fitness gains during repeated transfers of large virus populations in cell culture. Results always show that fitness increases exponentially. Low fitness clones exhibi...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Novella, I S, Duarte, E A, Elena, S F, Moya, A, Domingo, E, Holland, J J
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7597039/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.13.5841
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