Exponential increases of RNA virus fitness during large population transmissions.

The great adaptability shown by RNA viruses is a consequence of their high mutation rates. Here we investigate the kinetics of virus fitness gains during repeated transfers of large virus populations in cell culture. Results always show that fitness increases exponentially. Low fitness clones exhibi...

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Библиографические подробности
Главные авторы: Novella, I S, Duarte, E A, Elena, S F, Moya, A, Domingo, E, Holland, J J
Формат: Artigo
Язык:Inglês
Опубликовано: 1995
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC41597/
https://ncbi.nlm.nih.gov/pubmed/7597039
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