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Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation

Mutations in GATA4 and TBX5 are associated with congenital heart defects in humans. Interaction between GATA4 and TBX5 is important for normal cardiac septation, but the underlying molecular mechanisms are not well understood. Here, we show that Gata4 and Tbx5 are co-expressed in the embryonic atria...

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Détails bibliographiques
Auteurs principaux: Misra, Chaitali, Chang, Sheng-Wei, Basu, Madhumita, Huang, Nianyuan, Garg, Vidu
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159147/
https://ncbi.nlm.nih.gov/pubmed/24858909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu215
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