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De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling
Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)–scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4159113/ https://ncbi.nlm.nih.gov/pubmed/25203443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001945 |
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