De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)–scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-...

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Detalhes bibliográficos
Main Authors: Del Vecchio, Catherine A., Feng, Yuxiong, Sokol, Ethan S., Tillman, Erik J., Sanduja, Sandhya, Reinhardt, Ferenc, Gupta, Piyush B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159113/
https://ncbi.nlm.nih.gov/pubmed/25203443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001945
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