CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells

We report the anti-leukemic potency of a unique biotargeted nanoscale liposomal nanoparticle (LNP) formulation of the spleen tyrosine kinase (SYK) P-site inhibitor C61. C61-loaded LNP were decorated with a murine CD19-specific monoclonal antibody directed against radiation-resistant CD19-receptor po...

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Main Authors: Myers, Dorothea E., Yiv, Seang, Qazi, Sanjive, Ma, Hong, Cely, Ingrid, Shahidzadeh, Anoush, Arellano, Martha, Finestone, Erin, Gaynon, Paul, Termuhlen, Amanda, Cheng, Jianjun, Uckun, Fatih
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158964/
https://ncbi.nlm.nih.gov/pubmed/24910947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ib00095a
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