Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir

PURPOSE: Dolutegravir (DTG) is an unboosted, integrase inhibitor for the treatment of HIV infection. Two studies evaluated the effects of efavirenz (EFV) and tipranavir/ritonavir (TPV/r) on DTG pharmacokinetics (PK) in healthy subjects. METHODS: The first study was an open-label crossover where 12 s...

Full description

Saved in:
Bibliographic Details
Main Authors: Song, Ivy, Borland, Julie, Chen, Shuguang, Guta, Phyllis, Lou, Yu, Wilfret, David, Wajima, Toshihiro, Savina, Paul, Peppercorn, Amanda, Castellino, Stephen, Wagner, David, Hosking, Louise, Mosteller, Michael, Rubio, Justin P., Piscitelli, Stephen C.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2014
Subjects:
Clinical Trial
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158172/
https://ncbi.nlm.nih.gov/pubmed/25146692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-014-1732-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items