Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir

PURPOSE: Dolutegravir (DTG) is an unboosted, integrase inhibitor for the treatment of HIV infection. Two studies evaluated the effects of efavirenz (EFV) and tipranavir/ritonavir (TPV/r) on DTG pharmacokinetics (PK) in healthy subjects. METHODS: The first study was an open-label crossover where 12 s...

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Hlavní autoři: Song, Ivy, Borland, Julie, Chen, Shuguang, Guta, Phyllis, Lou, Yu, Wilfret, David, Wajima, Toshihiro, Savina, Paul, Peppercorn, Amanda, Castellino, Stephen, Wagner, David, Hosking, Louise, Mosteller, Michael, Rubio, Justin P., Piscitelli, Stephen C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2014
Témata:
Clinical Trial
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158172/
https://ncbi.nlm.nih.gov/pubmed/25146692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-014-1732-8
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