Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer

BACKGROUND: Thymoquinone (TQ) was shown to reduce tumor growth in several cancer models both in vitro and in vivo. So far only a few targets of TQ, including protein kinases have been identified. Considering that kinases are promising candidates for targeted anticancer therapy, we studied the comple...

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Главные авторы: El-Baba, Chirine, Mahadevan, Vijayalakshmi, Fahlbusch, Fabian B, S, Suma Mohan, Rau, Tilman T, Gali-Muhtasib, Hala, Schneider-Stock, Regine
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158125/
https://ncbi.nlm.nih.gov/pubmed/25174975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-201
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