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CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report...

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書誌詳細
主要な著者: Green, Kathy A., Ahonen, Cory L., Cook, W. James, Green, William R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC415804/
https://ncbi.nlm.nih.gov/pubmed/15141004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.6055-6060.2004
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