CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency

LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report...

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Vydáno v:	J Virol
Hlavní autoři:	Green, Kathy A., Ahonen, Cory L., Cook, W. James, Green, William R.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2004
Témata:	Pathogenesis and Immunity
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415804/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15141004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.11.6055-6060.2004
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