Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits aortic aneurysm initiation and progression in mice

OBJECTIVE: Macrophages are critical contributors in abdominal aortic aneurysm (AAA) disease. We examined the ability of MKEY, a peptide inhibitor of CXCL4-CCL5 interaction, to influence AAA progression in murine models. METHODS AND RESULTS: AAAs were created in 10-week-old male C57BL/6 mice by trans...

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Detalhes bibliográficos
Main Authors: Iida, Yasunori, Xu, Baohui, Xuan, Haojun, Glover, Keith J., Tanaka, Hiroki, Hu, Xiaolei, Fujimura, Naoki, Wang, Wei, Schultz, Joshua R., Turner, Court R., Dalman, Ronald L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158029/
https://ncbi.nlm.nih.gov/pubmed/23288157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300329
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