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Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits aortic aneurysm initiation and progression in mice
OBJECTIVE: Macrophages are critical contributors in abdominal aortic aneurysm (AAA) disease. We examined the ability of MKEY, a peptide inhibitor of CXCL4-CCL5 interaction, to influence AAA progression in murine models. METHODS AND RESULTS: AAAs were created in 10-week-old male C57BL/6 mice by trans...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4158029/ https://ncbi.nlm.nih.gov/pubmed/23288157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300329 |
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