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Integrase-Specific Enhancement and Suppression of Retroviral DNA Integration by Compacted Chromatin Structure In Vitro

Integration of viral DNA into the host chromosome is an obligatory step in retroviral replication and is dependent on the activity of the viral enzyme integrase. To examine the influence of chromatin structure on retroviral DNA integration in vitro, we used a model target comprising a 13-nucleosome...

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Udgivet i:J Virol
Principais autores: Taganov, Konstantin D., Cuesta, Isabel, Daniel, René, Cirillo, Lisa Ann, Katz, Richard A., Zaret, Kenneth S., Skalka, Anna Marie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415796/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15140982/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.11.5848-5855.2004
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