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Correction of the coagulation defect in hemophilia using a factor Xa variant with novel engineered protease function
Effective therapies are needed to control excessive bleeding in a range of clinical conditions. We describe a surprisingly useful approach to improve hemostasis in vivo using a variant of coagulation factor Xa (FXa(I16L)). This conformationally pliant derivative is partially inactive due to a defect...
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| Autors principals: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4157830/ https://ncbi.nlm.nih.gov/pubmed/22020385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1995 |
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