Matrix Expansion and Syncytial Aggregation of Syndecan-1(+) Cells Underpin Villous Atrophy in Coeliac Disease

BACKGROUND: We studied the expression of sulphated glycosaminoglycans (GAGs) in coeliac disease (CD) mucosa, as they are critical determinants of tissue volume, which increases in active disease. We also examined mucosal expression of IL-6, which stimulates excess GAG synthesis in disorders such as...

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Main Authors: Salvestrini, Camilla, Lucas, Mark, Lionetti, Paolo, Torrente, Franco, James, Sean, Phillips, Alan D., Murch, Simon H.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157760/
https://ncbi.nlm.nih.gov/pubmed/25198673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106005
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