Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

BACKGROUND & AIMS: Farnesoid X receptor (FXR, NR1H4) is a ligand-activated transcription factor, belonging to the nuclear receptor superfamily. FXR is highly expressed in the liver and is essential in regulating bile acid homeostasis. FXR deficiency is implicated in numerous liver diseases and m...

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Main Authors: Zhan, Le, Liu, Hui-Xin, Fang, Yaping, Kong, Bo, He, Yuqi, Zhong, Xiao-bo, Fang, Jianwen, Wan, Yu-Jui Yvonne, Guo, Grace L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157742/
https://ncbi.nlm.nih.gov/pubmed/25198545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105930
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