A Bioengineered Hydrogel System Enables Targeted and Sustained Intramyocardial Delivery of Neuregulin, Activating the Cardiomyocyte Cell Cycle and Enhancing Ventricular Function in a Murine Model of Ischemic Cardiomyopathy

BACKGROUND: Neuregulin (NRG) is a member of the epidermal growth factor family possessing a critical role in cardiomyocyte development and proliferation. Systemic administration of NRG demonstrated efficacy in cardiomyopathy animal models, leading to clinical trials employing daily NRG infusions. Th...

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Autori principali: Cohen, Jeffrey E., Purcell, Brendan P., MacArthur, John W., Mu, Anbin, Shudo, Yasuhiro, Patel, Jay B., Brusalis, Christopher M., Trubelja, Alen, Fairman, Alexander S., Edwards, Bryan B., Davis, Mollie S., Hung, George, Hiesinger, William, Atluri, Pavan, Margulies, Kenneth B., Burdick, Jason A., Woo, Y. Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157671/
https://ncbi.nlm.nih.gov/pubmed/24902740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.001273
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