Non-canonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens

Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal epithelial cells, which represent the first line of defense against enteric pathogens, remains unknown. We observed enhanced Salmonella enterica s...

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Hauptverfasser: Knodler, Leigh A., Crowley, Shauna M., Sham, Ho Pan, Yang, Hyungjun, Wrande, Marie, Ma, Caixia, Ernst, Robert K., Steele-Mortimer, Olivia, Celli, Jean, Vallance, Bruce A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157630/
https://ncbi.nlm.nih.gov/pubmed/25121752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.07.002
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