Molecular Imaging of Hypoxia-Inducible Factor 1α and von Hippel-Lindau Interaction in Mice

Tumor hypoxia plays a crucial role in tumorigenesis. Under hypoxia, hypoxia-inducible factor 1α (HIF-1α) regulates activation of genes promoting malignant progression. Under normoxia, HIF-1α is hydroxylated on prolines 402 and 564 and is targeted for ubiquitin-mediated degradation by interacting wit...

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Main Authors: Choi, Clara Y.H., Chan, Denise A., Paulmurugan, Ramasamy, Sutphin, Patrick D., Le, Quynh-Thu, Koong, Albert C., Zundel, Wayne, Gambhir, Sanjiv S., Giaccia, Amato J.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157628/
https://ncbi.nlm.nih.gov/pubmed/19123984
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