ARF and p53 coordinate tumor suppression of an oncogenic IFN-β-STAT1-ISG15 signaling axis

The ARF and p53 tumor suppressors are thought to act in a linear pathway to prevent cellular transformation in response to various oncogenic signals. Here we show that loss of p53 function leads to an increase in ARF protein levels which function to limit the proliferation and tumorigenicity of p53-...

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Hlavní autoři: Forys, Jason T., Kuzmicki, Catherine E., Saporita, Anthony J., Winkeler, Crystal L., Maggi, Leonard B., Weber, Jason D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157460/
https://ncbi.nlm.nih.gov/pubmed/24726362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.026
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