The Shc locus regulates insulin signaling and adiposity in mammals

Longevity of a p66Shc knockout strain (ShcP) was previously attributed to increased stress resistance and altered mitochondria. Microarrays of ShcP tissues indicated alterations in insulin signaling. Consistent with this observation, ShcP mice were more insulin sensitive and glucose tolerant at orga...

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Hlavní autoři: Tomilov, Alexey A., Ramsey, Jon J., Hagopian, Kevork, Giorgio, Marco, Kim, Kyoungmi M., Lam, Adam, Migliaccio, Enrica, Lloyd, Kent C., Berniakovich, Ina, Prolla, Tomas A., Pelicci, PierGiuseppe, Cortopassi, Gino A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157392/
https://ncbi.nlm.nih.gov/pubmed/21040401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2010.00641.x
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