Neutral Polymer Micelle Carriers with pH-Responsive, Endosome-Releasing Activity Modulate Antigen Trafficking to Enhance CD8 T-Cell Responses

Synthetic subunit vaccines need to induce CD8(+) cytotoxic T-cell (CTL) responses for effective vaccination against intracellular pathogens. Most subunit vaccines primarily generate humoral immune responses, with a weaker than desired CD8(+) cytotoxic T-cell response. Here, a neutral, pH-responsive...

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Bibliografiske detaljer
Main Authors: Keller, Salka, Wilson, John T, Patilea, Gabriela I, Kern, Hanna B, Convertine, Anthony J, Stayton, Patrick S
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156909/
https://ncbi.nlm.nih.gov/pubmed/24698946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.03.041
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