Modulating Hydrogel Crosslink Density and Degradation to Control Bone Morphogenetic Protein Delivery and In Vivo Bone Formation

Bone morphogenetic proteins (BMPs) show promise in therapies for improving bone formation after injury; however, the high supraphysiological concentrations required for desired osteoinductive effects, off-target concerns, costs, and patient variability have limited the use of BMP-based therapeutics....

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Bibliografiske detaljer
Main Authors: Holloway, Julianne L., Ma, Henry, Rai, Reena, Burdick, Jason A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156908/
https://ncbi.nlm.nih.gov/pubmed/24905414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.05.053
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