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pH-Responsive and Enzymatically-Responsive Hydrogel Microparticles for the Oral Delivery of Therapeutic Proteins: Effects of Protein Size, Crosslinking Density, and Hydrogel Degradation on Protein Delivery
Two potential platform technologies for the oral delivery of protein therapeutics were synthesized and tested. pH-Responsive poly(itaconic acid-co-N-vinyl-2-pyrrolidone) (P(IA-co-NVP)) hydrogel microparticles were tested in vitro with model proteins salmon calcitonin, urokinase, and rituximab to det...
Shranjeno v:
| izdano v: | J Control Release |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4734382/ https://ncbi.nlm.nih.gov/pubmed/26616761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.11.023 |
| Oznake: |
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