pH-Responsive and Enzymatically-Responsive Hydrogel Microparticles for the Oral Delivery of Therapeutic Proteins: Effects of Protein Size, Crosslinking Density, and Hydrogel Degradation on Protein Delivery

Two potential platform technologies for the oral delivery of protein therapeutics were synthesized and tested. pH-Responsive poly(itaconic acid-co-N-vinyl-2-pyrrolidone) (P(IA-co-NVP)) hydrogel microparticles were tested in vitro with model proteins salmon calcitonin, urokinase, and rituximab to det...

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Veröffentlicht in:J Control Release
Hauptverfasser: Koetting, Michael Clinton, Guido, Joseph Frank, Gupta, Malvika, Zhang, Annie, Peppas, Nicholas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734382/
https://ncbi.nlm.nih.gov/pubmed/26616761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.11.023
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