Mucosal Vaccine Made from Live, Recombinant Lactococcus lactis Protects Mice against Pharyngeal Infection with Streptococcus pyogenes

A novel vaccine (LL-CRR) made from live, nonpathogenic Lactococcus lactis that expresses the conserved C-repeat region (CRR) of M protein from Streptococcus pyogenes serotype 6 was tested in mice. Nasally vaccinated mice produced CRR-specific salivary immunoglobulin A (IgA) and serum IgG. Subcutaneo...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Mannam, Praveen, Jones, Kevin F., Geller, Bruce L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415684/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15155651/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.6.3444-3450.2004
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