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Mucosal Vaccine Made from Live, Recombinant Lactococcus lactis Protects Mice against Pharyngeal Infection with Streptococcus pyogenes

A novel vaccine (LL-CRR) made from live, nonpathogenic Lactococcus lactis that expresses the conserved C-repeat region (CRR) of M protein from Streptococcus pyogenes serotype 6 was tested in mice. Nasally vaccinated mice produced CRR-specific salivary immunoglobulin A (IgA) and serum IgG. Subcutaneo...

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Autores principales: Mannam, Praveen, Jones, Kevin F., Geller, Bruce L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC415684/
https://ncbi.nlm.nih.gov/pubmed/15155651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.6.3444-3450.2004
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