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Attenuation of Replication Stress–Induced Premature Cellular Senescence to Assess Anti-Aging Modalities
Described is an in vitro model of premature senescence in pulmonary adenocarcinoma A549 cells induced by persistent DNA replication stress in response to treatment with the DNA damaging drug mitoxantrone (Mxt). The degree of cellular senescence, based on characteristic changes in cell morphology, is...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156839/ https://ncbi.nlm.nih.gov/pubmed/24984966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/0471142956.cy0947s69 |
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