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Enhancement of Anthrax Lethal Toxin Cytotoxicity: a Subset of Monoclonal Antibodies against Protective Antigen Increases Lethal Toxin-Mediated Killing of Murine Macrophages

We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage cell lines. Anthrax PA plays a critical role in the pathogenesis of Bacillus anthracis infection. PA...

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書誌詳細
主要な著者: Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., Casey, Leslie S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC415670/
https://ncbi.nlm.nih.gov/pubmed/15155630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.6.3276-3283.2004
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