Enhancement of Anthrax Lethal Toxin Cytotoxicity: a Subset of Monoclonal Antibodies against Protective Antigen Increases Lethal Toxin-Mediated Killing of Murine Macrophages

We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage cell lines. Anthrax PA plays a critical role in the pathogenesis of Bacillus anthracis infection. PA...

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Bibliographic Details
Main Authors: Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., Casey, Leslie S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC415670/
https://ncbi.nlm.nih.gov/pubmed/15155630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.6.3276-3283.2004
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