Experimental Pneumococcal Meningitis: Impaired Clearance of Bacteria from the Blood Due to Increased Apoptosis in the Spleen in Bcl-2-Deficient Mice

Necrotic and apoptotic neuronal cell death can be found in pneumococcal meningitis. We investigated the role of Bcl-2 as an antiapoptotic gene product in pneumococcal meningitis using Bcl-2 knockout (Bcl-2(−/−)) mice. By using a model of pneumococcal meningitis induced by intracerebral infection, Bc...

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Bibliografiske detaljer
Main Authors: Wellmer, Andreas, von Mering, Matthias, Spreer, Annette, Diem, Ricarda, Eiffert, Helmut, Noeske, Christiane, Bunkowski, Stefanie, Gold, Ralf, Nau, Roland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC415656/
https://ncbi.nlm.nih.gov/pubmed/15155612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.6.3113-3119.2004
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