Experimental Pneumococcal Meningitis: Impaired Clearance of Bacteria from the Blood Due to Increased Apoptosis in the Spleen in Bcl-2-Deficient Mice

Necrotic and apoptotic neuronal cell death can be found in pneumococcal meningitis. We investigated the role of Bcl-2 as an antiapoptotic gene product in pneumococcal meningitis using Bcl-2 knockout (Bcl-2(−/−)) mice. By using a model of pneumococcal meningitis induced by intracerebral infection, Bc...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Wellmer, Andreas, von Mering, Matthias, Spreer, Annette, Diem, Ricarda, Eiffert, Helmut, Noeske, Christiane, Bunkowski, Stefanie, Gold, Ralf, Nau, Roland
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2004
Assuntos:	Host Response and Inflammation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15155612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.6.3113-3119.2004
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